The Triazole and its derivatives are an important class of nitrogen containing compounds. Triazole compounds in plant growth regulating specific aspects can be demonstrated, for the study of plant growth regulator has opened up new areas. Compared with other fungicides, Triazole fungicides with high efficiency, low toxicity, resistance, double effectiveness ( sterilization, controlled long ), extensive features, the most promising type of fungicide.
In terms of medical treatment, five nitrogen heterocyclic compounds because of its physiological function in a wide range of new drug research as a pharmacophore is concerned, of which Triazole compounds as antiviral ribavirin and antifungal fluconazole has been successfully applied in clinical. In the middle of the last century, people found in the study of Triazole catalase were Benzotriazole mammalian cells inhibited, by increasing the intracellular levels of H2O2 cytotoxicity caused by this, Triazole as cytotoxic potential antitumor drugs have been widely studied.
So far, domestic and foreign research institutions many to synthesize ideas and different synthetic routes to synthesize three Triazole derivatives a lot. Three nitrogen thiazole derivatives, many kinds of complex structure, many compounds exhibit strong inhibition of tumor cell proliferation, block cell cycle progression, induction of apoptosis and cell differentiation and other biological activity. Further study in scientific research workers of three Triazole compounds, contribute to the widespread development of anticancer drugs with novel structure, high activity, low toxicity, high selectivity.
In the industry, in the 1960s, the scientists from the United Kingdom propose that Benzotriazole can be used as vapor phase corrosion inhibitor of copper and its alloys. And so far, in the industry, we usually use Benzotriazole and other organic corrosion inhibitors as corrosion inhibitor for copper. Triazole compounds on the metal surface has excellent adsorption performance, can effectively inhibit the acid corrosion of the metal. As Triazole compounds having a planar delocalized conjugated system, can be frontier molecular orbital interaction with the metal surface, preventing the occurrence of corrosion reaction, while the polarity of the molecule itself, it is possible by the electrostatic attraction of the metal cover surface, the metal surface with corrosion medium isolation, played the role of slow rot. In 1990s, the experts successfully applied to the iron relics protection, and thus the application of Triazole compounds ranging from non ferrous metals expanded to black metals. So far, the bronze relics protection is the most widely used methods of vapor phase corrosion inhibition, and BTA is most widely used in a variety of vapor phase corrosion inhibitors.