Two kinds of biocompatible polymer materials, Sodium Alginate and Polyvinyl Alcohol, as the main raw material. In situ cross-linking technology to prepare a new class of hydrogel dressing matrix. By rheological tests found the resulting hydrogel dressing matrix is a non -Newtonian fluid, with shear thinning properties. And that when alginate mass fraction is 0.10, hole- dosage in the range of 0-5%, can be obtained having excellent rheological properties , storage stability and mechanical properties of the hydrogel dressing matrix.
Experiments show that the dressing matrix has good biological safety.
Use Vitamin B12, Bovine Serum Albumin (BSA) as a model drug, study the effects of the drug release kinetics of the hydrogel dressing matrix, found that by a model drug release behavior of this dressing matrix equation can be used to describe Peppas, and has sustained-release effect. The same time, the mass fraction of Sodium Alginate of 0.10 percent release drug system maximum. With the increase of the percentage of drug release system while increasing the dosage hole. Dressing matrix in an alkaline medium is less than the percentage of release in acidic media release percentage. Dressing matrix for drug release with the increase in the percentage of crosslinking agent is reduced. Showed that by changing the mass fraction of sodium alginate, hole- dosage, PH value and the release medium crosslinking agent to regulate drug release. In addition, place 14 days after the release of the EGF dressing matrix curve and just prepared for EGF release matrix dressing percentage similar to the description of the resulting gel dressing has a storage stability.
By swelling kinetics experiments, hydrogel dressing matrix prepared found strong liquid absorption capacity, a large amount of liquid can be absorbed in a short time. By scanning electron microscopy, it has comfirmed that inside the prepared hydrogel dressing matrix presence permeability porous structure.